How does fatty liver disease cause jaundice?

May 4, 2025

The Non Alcoholic Fatty Liver Strategy™ By Julissa Clay the program discussed in the eBook, Non Alcoholic Fatty Liver Strategy, has been designed to improve the health of your liver just by eliminating the factors and reversing the effects caused by your fatty liver. It has been made an easy-to-follow program by breaking it up into lists of recipes and stepwise instructions. Everyone can use this clinically proven program without any risk. You can claim your money back within 60 days if its results are not appealing to you.


How does fatty liver disease cause jaundice?

Jaundice, yellowing of the skin and of the white portion of the eye, is caused by the buildup of bilirubin in the blood. Bilirubin is a product of breakdown in the red cells by the liver. Normally in healthy individuals, the liver degrades bilirubin and drains it out through bile from the body. However, in some diseases like fatty liver disease, this physiological role is affected to lead to jaundice.

Here’s how fatty liver disease can cause jaundice:

1. Impaired Liver Function
In fatty liver disease, fat accumulates in liver cells, which may lead to inflammation and fibrosis (in advanced stages). This injury impairs the function of the liver to perform many of its important functions, including processing and removing bilirubin. When the liver fails to process bilirubin properly, it begins to accumulate in the blood, causing jaundice.

2. Hepatitis (Liver Inflammation)
When fatty liver disease progresses to non-alcoholic steatohepatitis (NASH)—a more severe condition where the liver becomes inflamed—the inflammation further damages the liver cells. This inflammation can result in:

Disruption of bilirubin processing: Damaged liver cells cannot break down and process bilirubin properly.

Bilirubin buildup: As a result, bilirubin builds up in the blood, causing the skin and eyes to turn yellow.

3. Liver Cirrhosis (Advanced Scarring)
In advanced fatty liver disease, when cirrhosis happens, the liver becomes seriously scarred. Scarring can block bile flow (which is responsible for carrying bilirubin out of the liver) and also impair liver function. The inability to remove bilirubin through bile channels causes it to accumulate in the body, leading to jaundice.

4. Impaired Bile Flow
The liver secretes bile, which facilitates fat digestion and the elimination of waste products like bilirubin. In severe fatty liver disease or cirrhosis, the liver may be compromised in its function to secrete bile or bile flow can be obstructed. This process results in the buildup of bilirubin in the blood since it can’t be secreted properly.

5. Toxin-Induced Liver Damage
In fatty liver in its advanced stage, the liver not only fails to metabolize fats but also finds it hard to detoxify poisonous substances. If the liver is clogged with toxins or fat deposits, its ability to metabolize and eliminate bilirubin decreases, resulting in its accumulation in the body, causing jaundice.

Symptoms and signs of Jaundice in Fatty Liver Disease:
Yellow coloration of the eyes and skin (scleral icterus)

Dark urine due to the kidneys releasing excess bilirubin

Light-colored stools (not enough bile in the intestines)

Fatigue and weakness

Itching (pruritus) due to the accumulation of bile salts under the skin

Treatment of Jaundice in Fatty Liver Disease:
Treatment of the underlying fatty liver disease is a must. This can include:

Weight loss (if overweight or obese)

A healthy, balanced diet

Exercise

Treatment of any other diseases, for instance, diabetes or high cholesterol

Abstinence from alcohol is crucial to avoid further liver damage.

Drugs: In acute cases, drugs may be administered to manage liver inflammation or other complications.

Liver transplantation may be considered in advanced cases of cirrhosis.

If jaundice ever does occur, you need to see the doctor immediately because jaundice may indicate severe malfunction of the liver. Do you want to know how to avert or manage jaundice in the event of fatty liver disease?

Chronic fatty liver disease, particularly when it is established (such as non-alcoholic steatohepatitis (NASH), fibrosis, or cirrhosis), could lead to all manner of manifestations due to injury, impaired liver function, and complications. Once the disease becomes established, there is scarring, inflammation of the liver, and decreased capability to perform the normal functions. The following represent the common manifestation of established fatty liver disease:

1. Pronounced Abdominal Pain or Discomfort
Recurrent pain in the right upper region of the abdomen that worsens over time could be due to enlargement or inflammation of the liver.

The pain can be cutting or aching and refers to the shoulder or back.

2. Swelling (Ascites)
Fluid accumulation within the abdomen, known as ascites, is a common presentation in end-stage liver disease, especially cirrhosis.

This is followed by visible abdominal bloating and pain. It can also result in shortness of breath as it presses on the diaphragm.

3. Jaundice (Yellowing of the Eyes and Skin)
Jaundice is developed when liver function is badly impaired, preventing the production and release of bile, thereby resulting in jaundice.

Yellow coloring of the skin and whites of the eyes are the symptoms observed in extreme liver dysfunction.

4. Severe Fatigue and Weakness
As the liver becomes increasingly impaired, its role in detoxifying the body, storing nutrients, and producing energy-regulating proteins deteriorates.

This leads to ongoing fatigue, weakness, and general feeling of poor health.

5. Unexplained Weight Loss
Despite having a proper or increased appetite, unexplained weight loss is possible because of an inability of the liver to adequately and effectively break down nutrients, leading to malnutrition.

In advanced cases, muscle wasting (cachexia) may also be noted.

6. Nausea, Vomiting, and Loss of Appetite
Patients with end-stage liver disease often experience chronic nausea, vomiting, and loss of appetite.

This is due to the liver’s inability to metabolize toxins and nutrients in a normal way, leading to gastrointestinal disturbances.

7. Spider Angiomas (Spider-Like Blood Vessels)
Small, red, spider-like blood vessels visible just beneath the skin surface, typically on the chest, face, or arms.

These can occur as a result of liver failure and changes in blood flow secondary to liver trauma.

8. Easy Bruising
The liver produces clotting factors. With decreased liver function, blood clotting is impaired, leading to easy bruising or nosebleeds.

9. Dark Urine
Dark yellow or brown urine can be a sign that the liver is not properly metabolizing bilirubin, a pigment that is normally excreted in bile.

10. Pale or Clay-Colored Stools
Clay-colored stools occur when the liver is unable to produce sufficient bile, leading to the lack of normal stool pigmentation.

11. Confusion or Cognitive Changes (Hepatic Encephalopathy)
As liver function declines, toxins like ammonia build up in the blood and damage the brain, leading to confusion, impaired concentration, personality changes, and even disorientation.

In severe cases, this can progress to hepatic encephalopathy, a life-threatening state leading to coma.

12. Itching Skin (Pruritus)
Itching is common in severe liver disease when bile salts in the skin are stored up. It is often quite troublesome and relentless.

13. Swollen or Bleeding Veins (Varices)
In cirrhosis, liver pressure (portal hypertension) may lead to the development of varices—distended veins in the esophagus or stomach.

The varices are dangerous to rupture and bleed very heavily, typically with vomiting blood or passing black, tarry stools.

14. Fluid in the Legs (Edema)
Edema or swelling of legs and ankles may also occur due to reduced albumin production by the liver, which is responsible for maintaining the balance of fluid in the body.

15. Liver Failure
In the advanced stages of fatty liver, the function of the liver may be so reduced that the liver may lose its vital functions (like detoxification, protein synthesis, and clotting of blood).

This can result in liver failure, a potentially life-threatening condition requiring prompt medical care, including liver transplantation in extreme cases.

16. Increased Risk of Liver Cancer (Hepatocellular Carcinoma)
Patients with advanced fatty liver disease, especially cirrhosis, are at higher risk for developing liver cancer.

Symptoms of liver cancer can include an abdominal mass, increasing abdominal pain, jaundice, and weight loss.

17. Increased Sensitivity to Medications
As liver function slows down, the ability of the body to process drugs is impaired, resulting in increased sensitivity to medication and higher chances of side effects.

If you experience these symptoms, or you have someone with whom you associate them, immediate medical attention must be sought. With early treatment, symptoms may be controlled, progression of the disease slowed down, and further damage to the liver prevented.

Would you prefer to have information on treatment or lifestyle changes to manage severe fatty liver disease?

The Non Alcoholic Fatty Liver Strategy™ By Julissa Clay the program discussed in the eBook, Non Alcoholic Fatty Liver Strategy, has been designed to improve the health of your liver just by eliminating the factors and reversing the effects caused by your fatty liver. It has been made an easy-to-follow program by breaking it up into lists of recipes and stepwise instructions. Everyone can use this clinically proven program without any risk. You can claim your money back within 60 days if its results are not appealing to you